How homologs help to predict protein folds

Rykunov D.S.1, Lobanov M.Yu.2, Reva B.A.3,4, Finkelstein A.V.2

1Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142292 Pushchino, Moscow Region, Russia

2Institute of Protein Research, Russian Academy of Sciences, 142292 Pushchino, Moscow Region, Russia

3Institute of Mathematical Problems of Biology, Russian Academy of Sciences, 142292 Pushchino, Moscow Region, Russia

4The Scripps Research Institute, Dept. of Mol.Biology, TPC5, 10550 N. Torrey Pines Rd,La Jolla, CA 92037.

It is shown that fold recognition by both no-gap and gapped threading is improved significantly when a set of homologous sequences rather than only one of them is used.